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Archive for the ‘PROSTATE RISKS’ Category

URO TODAY: Canadian researchers have found significant links between prostate cancer and a range of agricultural and gardening chemicals also used at various times in New Zealand.

These include DDT, simazine, lindane, dichlone, dinoseb amine, malathion, endosulfan, 2,4-D, 2,4-DB, and carbaryl. READ MORE>

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NEWSWIRE NZ:  NZ scientific bodies, apple growers and others say they know nothing about the possible use of cancer-causing apply spray Kepone here in the 60s and early 70s. READ MORE>

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BBC NEWS: A BRCA2 gene mutation can increase risk of prostate cancer by up to seven-fold, while a BRACA1 mutation is thought to double risk in men under 65 years old, a study shows. READ MORE>

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URO TODAY: The WASF3 protein plays a critical role in the progression of prostate cancer and is a potential target to control tumorigenicity and metastasis. READ MORE>

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URO TODAY: Men with metabolic syndrome – obesity/heart disease/diabetes – have a greater risk of getting prostate cancer, especially if they suffered from the syndrome by the time they turned 50, scientists have discovered. READ MORE>

Men having metabolic syndrome had a modestly higher risk of developing prostate cancer than men not having MetS criteria.

The conditional probability of being diagnosed with prostate cancer age 80 years was statistically significantly higher in men with MetS at age 50 years.

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PROSTABLOG NZ: An insecticide used in New Zealand to control an apple pest during the 60s and early 70s may have greatly increased prostate cancer risk.

The insecticide – an organochlorine marketed under the name Kepone – caused such widespread environmental damage the US maker stopped production in 1976 and the World Health Organisation later banned it.

Researchers have now found evidence its widespread use to control a banana plant pest in the French West Indies for 30 years significantly raised the incidence of prostate cancer among men there.

A suggestion the chemical (first produced in 1958) might be dangerous came in 1964 when two New Zealand agricultural scientists, H.V. Brewerton and D.A. Slade, published the first findings about Kepone’s ability to remain in edible plants.

They analysed Nelson-produced apples that had been sprayed for leaf roller as many as 13 times during growth. The apples showed heavy residues of spray on skin and in the pulp.

At present, no tolerance has been established for “Kepone”, and owing to the evident high persistence of the chemical, its use cannot at present be suggested even in the early season.

However, a 1.5 parts per million tolerance would enable “Kepone” to be used on Sturmer apples up to the end of December, and under New Zealand conditions this would make a worthwhile contribution to the control of leaf roller.

In 1975, workers at the factory making the insecticide in the US were found to be suffering a mystery illness and their town was found to be heavily contaminated.

Later research in the 70s and early 80s found the chemical in Kepone, chlordecone, caused illnesses, including cancer, and infertility.

French scientists recently published their findings in the Journal of Clinical Oncology, after testing the blood of 623 French West Indian men who suffered prostate cancer and comparing them with a random sample of 671 males:

We found a significant increase in the risk of prostate cancer with increasing plasma (blood) chlordecone concentration…

…Stronger associations were observed among those with a positive family history of prostate cancer and among those who had lived in a Western country.

…Also, a significantly higher risk existed for patients older than 60 years compared to younger than 60 years.

…These findings support the hypothesis that exposure to environmental estrogens increases the risk of prostate cancer.

Chlordecone was used between 1973 and 1993 in the French West Indies as an insecticide in banana plants.

It caused widespread contamination of soil, water, animals and vegetables.

Chlordecone does not undergo significant degradation, so polluted sources continue to contaminate foodstuffs which remain the primary means of human exposure to this chemical.

Chlordecone is a known carcinogen in laboratory models and its hormonal properties and long half-life increase the possibility of acting as a carcinogen.

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NEW PROSTATE CANCER INFOLINK: Prostate cancer is linked to gene variations we inherit, but there are other factors involved as well, writes Mike Scott. READ MORE>

It is all too easy to want to believe that prostate cancer (and other forms of cancer) might be like one of the truly heritable diseases that are utterly dependent on one’s genetics, such as sickle cell anemia or Huntington’s disease.

Unfortunately, it just isn’t going to be that simple.

The development of prostate cancer in any specific individual is most probably a multi-stage process.

It may well be linked to the genes you are born with, but it is also quite certainly linked to other things that happen as you age.

As yet, we have minimal understanding of what those “other things” really are.

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URO TODAY: Eating food with high trans fat content increases the risk of prostate cancer – but other possible risks like cholesterol, total proteins, total fat, mono-unsaturated fats, poly-unsaturated fats, mono-saccharides and total carbohydrates don’t rate.

These are the findings of a survey of 1800 men across eight Canadian provinces. READ MORE>

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UK TELEGRAPH: Merely having asthma increases a man’s likelihood of developing prostate cancer by 26 per cent and inhalers don’t help. READ MORE>

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URO TODAY: Statin use is associated with a decreased risk of prostate cancer diagnosis, a survey of nearly 2500 men found. READ MORE>

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