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Archive for the ‘Chemotherapy’ Category

Publicly funded chemotherapy clinics in NZ have increased 25% in two years, to just over 57,000 outpatient sessions in public hospitals in the 2009/10 year, says Health Minister Tony Ryall. READ MORE>

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HEALTH NEWS TODAY: When combined with the erectile-dysfunction drug Viagra, a long-used chemotherapy drug called doxorubicin may be even more effective as a treatment for prostate cancer, according to a new study. READ MORE>

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WALL ST JOURNAL: The US Food and Drug Administration has approved Jevtana, a chemotherapy drug used in combination with the steroid prednisone to treat men with advanced prostate cancer. READ MORE> and HERE>

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URO TODAY:  Abiraterone acetate is a promising treatment for advanced prostate cancer patients and is being tested in a Phase III trial for men with progressive castration-resistant prostate cancer who have  not had chemotherapy.

A Phase III trial for patients following prior chemotherapy has been completed and is awaiting analysis. READ MORE>

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URO TODAY:  The five main prostate cancer treatments can all have bad side effects, so a panel of 15 specialists have compared them and come up with some recommended improvements.

Prostate cancer (PC) is one of the tumours with the highest incidence in recent years. PC therapies have several adverse effects.

A panel consensus recommendation has been made to prevent or ameliorate complications in PC treatment to improve quality of life.

Fifteen specialists have met to analyse the different toxicities associated with PC treatment.

Each medical specialist searched National Library of Medicine PubMed citations about these secondary effects and his specialty from 1999 to 2009 to propose measures for their prevention/amelioration.

  • Surgery is associated with incontinence and impotence.
  • Radiotherapy can produce acute, late urological and gastrointestinal toxicity.
  • Brachytherapy can produce acute urinary retention.
  • Chemotherapy is associated with haematotoxicity. peripheral neuropathy and diarrhoea.
  • And hormone therapy can produce osteoporosis, metabolic syndrome, cognitive and muscular alterations, cardiotoxicity, etc.

Improvement in surgical techniques and technology (IMRT/IGRT) can prevent surgical and radiotherapeutic toxicity, respectively.

Brachytherapy toxicity can be prevented with precise techniques to preserve the urethra.

Chemotherapy toxicity can be prevented with personalized schedules of treatment and close follow-up of iatrogenia

And hormone therapy toxicity can be prevented with close follow-up of possible secondary effects.

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SCIENCE DAILY: A combination of radiation therapy and chemotherapy given before prostate removal is safe and may have the potential to reduce cancer recurrence and improve patient survival. READ MORE>

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URO TODAY: A combination of docetaxel/zoledronic/prednisone in chemotherapy for hormone refractory prostate cancer patients is safe and effective, say Indian researchers. For patients with a Gleason score less than 7, PSA declined more than 50% and those who received more than four cycles had significantly better survival. READ MORE>

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MEDICAL NEWS TODAY: In trying to better predict a patient’s response to chemotherapy, a team of investigators at the State University of New Jersey has identified a way to better manipulate a gene product to cause cancer cells to die. READ MORE>

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MEDICAL NEWS TODAY: A phase 3 clinical trial of the investigational drug MDV3100 for advanced prostate cancer has just begun in the US. READ MORE>

Known as AFFIRM, the trial will evaluate the novel androgen receptor antagonist MDV3100 in men with castration-resistant prostate cancer who were previously treated with .

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URO TODAY: Scientists in Texas have been analysing data on the considerable number of castration-refractory prostate cancer patients who experience an initial PSA surge/flare-up while having chemotherapy. READ MORE>

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