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Archive for the ‘Biochemical recurrence’ Category

URO TODAY: The rate of increase in PSA level prior to prostate cancer surgery is an indicator of your long-term survival, research shows. READ MORE>

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URO TODAY: Researchers have investigated associations between 29 single nucleotide polymorphisms (SNP) and biochemical recurrence, castration-resistant metastasis, and prostate cancer-specific survival, and found the SNPs are a clue to outcomes. READ MORE>

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PROSTABLOG NZ: Sooo…another nil PSA test, 60 weeks after the prostatectomy.

So far, so good.

I guess the next hurdle is two years out (from the surgery on March 25, 2009), when – according to the reading I’ve done – if the prostate cancer is going to flare up again, that’s when the first sign is likely to show in rising PSA.

Here’s my PSA readings over the past couple of years:

  • August 30, 2007: 0.9
  • November 28, 2008: 0.7 – this was when a digital exam first discovered cancer.

MARCH 25, 2009: Radical prostatectomy

  • August 6, 2009: <0.05
  • January 29, 2010: <0.05
  • May 21, 2010: <0.05

Note the PSA was never very high, which reinforces the message I give to anyone who’ll listen – get both the PSA and the digital exam, because some of us don’t show on PSA.

I’m hoping that no longer applies, of course. If I have recurrence, I want something to show up.

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URO TODAY: MRI scans after external beam radiation and radical prostatectomy treatments for prostate cancer are an accurate way of predicting recurrence of the disease, a US MRI expert says. READ MORE>

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URO TODAY: In cases of persistent PSA following radical prostatectomy for prostate cancer, three-dimensional conformal radio therapy can be used as monotherapy with a significant chance of recurrence free survival. READ MORE>

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URO TODAY: Dutch researchers testing the use of (11)C-choline positron emission tomography as a way to identify the site(s) of prostate cancer that has spread after external beam radiation say it is 84% accurate. READ MORE>

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URO TODAY: Salvage cryotherapy appears to be the treatment of choice for patients who have a rising PSA after radiation therapy, provided their PSA level is less than 4ng/ml and they were good candidates for local therapy prior to radiation therapy. READ MORE>

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PUB MED.COM: When biochemical recurrence occurs after initial prostate cancer treatment, prognostic factors for survival change, according to a new report from Australasian researchers (including NZ’s Professor David Lamb) who investigated at NZ and Australian patients. READ MORE>

Low initial PSA, short time to biochemical recurrence, and rapid PSA doubling time take over at this point, providing reasons why initial PSA and occurrence of biochemical recurrence alone predict prostate cancer-specific survival poorly.

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URO TODAY: A new ultra-sensitive nanoparticle-based assay – 300 times more sensitive than commercial immuno-assays – is capable of detecting previously undetectable levels of PSA in patients who have undergone radical prostatectomy. READ MORE>

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URO TODAY: What do you do when the pathologist reports “positive margins” after a radical prostatectomy? One of the world’s leading prostate cancer experts is studying the effects of post RRP treatment with radiotherapy in such cases. READ MORE>

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