Archive for the ‘METASTASIS’ Category

I should be cracking a bottle of fine bubbles about now – I’m more than a decade past my prostatectomy and there are no signs of prostate cancer.

Is it tempting fate to write that? Of course it is. I met someone a year or so back who got to 13 years with no show of C…then he got it.

Unusual, that. A decade was considered the magic milestone when I was writing about prostate cancer regularly (the first couple of years after my op). What is it now, I wonder? Is there even a safe zone any more? I’d rather not know.

The only time I think about it is when I hear from someone looking for a bit of advice and encouragement. Or when I look down at my greatly shortened appendage, the result of having your urinary tract sliced to get rid of the prostate and sewn back together again.

Nobody warns you about that. After the scars have all but disappeared, a short dick is just about all that’s left to remind you of the op. Small price to pay for life, of course, but irritating, nonetheless.

My wife, bless her, says she doesn’t even notice (she just said something indecent I can’t repeat here – yes, that function still works, too).

I do notice another change, but I suspect it’s the result of creeping age (I’m 73 now); my flow has slowed up considerably again.

I will never forget the joy of taking a slash once the op wounds healed and marvelling at the flow of an 18-year-old that cascaded into the bowl.

I was so excited at the time (2010) I shot a short video (no appendage in view) and posted it on this blog. Weirdly, some sicko complained to WordPress after a few months and they took it down. Give me strength.

Anyway, all is well. Look out for yourselves during Covid.

FOOTNOTE: Just cracked a bottle of fine bubbles with Lin, not just to celebrate the clear decade, but we just finished our latest book (my 21st).

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URO TODAY: For the first time, a study has shown that people who produce excess amounts of an enzyme called elongation factor 1alpha have a better chance of long-term survival from prostate cancer (at least I think that’s what this report says). READ MORE>

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URO TODAY: Medical researchers have described the case of a 61-year-old man who developed extensive tumours nine years after prostate cancer treatment, even though his PSA level was undetectable. READ MORE>

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URO TODAY: An experiment that combines a standard advanced prostate cancer drug treatment with a vaccine to assist the immune system has just begun in the US. READ MORE>

Looking to harness the body’s own immune system to target prostate cancer that has spread to the bones (metastatic) and is unresponsive to standard treatment, investigators have just launched a clinical trial combining vaccine and radiation drug therapy.

The goal is to see if disease progression will be further delayed by adding two different experimental injections to the standard treatment.

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IN-SCIENCES.ORG: Fucosylations – structures on the surface of prostate cancer cells – trigger prostate cancer cell adhesion inside a blood vessel wall in bone tissue, greatly increasing the prospect of prostate cancer cells metastasizing to bone. READ MORE>

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URO TODAY: A major obstacle in understanding the biology of advanced prostate cancer is clinicians’ limited ability to obtain metastatic tissue for study. READ MORE>

A new study shows that a method called a cellular-adhesion matrix (CAM) test tube-based platform is a minimally-invasive, feasible, and practical method for the study of metastatic prostate cancer, one which allows for the isolation, quantification, culture, and cellular and genomic characterisation of circulating metastatic tumour cells.

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JohnMary1JULY 10: PROSTABLOG NZ: “It’s sad that medical professionals in NZ are so scared of possible side effects from a treatment like Ketoconazole, that they refuse to even acknowledge it, even if it has been proven to be effective overseas.”

These words were written today by Mary – a Kiwi whose partner has advanced prostate cancer – as she describes the frustration of being unable to persuade NZ doctors to move outside what seem to her to be inflexible approaches to treatment.

“I produced prostate cancer digests from people I know who have had large drops in PSA on Keto, but I was told I know only a few people and trials showing side effects have been done on thousands,” she says.

“When I said I would like to see the papers on this, I was told I was not a doctor…and to this I respond “no, but I am the partner of a man with advanced cancer.”

READ the second chapter of Mary’s struggle to save her man.

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JUNE 30: URO TODAY: In selected patients with prostate cancer metastases to the spine, aggressive surgical decompression and spinal reconstruction is a useful treatment option. The results show that on average, neurological outcome is improved and use of analgesics is reduced. Gleason score, metastatic burden, and degree of spinal canal compression may be associated with survival following surgery, and thus should be considered carefully prior to opting for surgical management. READ MORE>

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JUNE 16: URO TODAY: Preventive measures against adverse effects and careful assessment of a patient’s baseline health status should be considered when using androgen deprivation therapy, say researchers in Texas. They found ADT is associated with an increased risk of skeletal fracture, incident diabetes, and cardiovascular-related mortality, although the absolute risk of these events is low. READ MORE>

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JUNE 13: CANCER CONSULTANTS.COM: Researchers report that treatment with human antibody denosumab significantly reduces the incidence of bone fracture in prostate cancer patients on androgen deprivation therapy. READ MORE>

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