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Archive for the ‘PSA tests’ Category

WEB MED: More than 75% of men diagnosed with low-risk prostate cancer undergo aggressive treatment — either complete removal of the prostate or radiation therapy, according to a new study.

That’s true, the researchers found, even in men with a low level of prostate-specific antigen (PSA) of under 4 nanograms per milliliter, one of the factors taken into account when treatment decisions are made. READ MORE>

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URO TODAY: The benefits of prostate-cancer screening compare favourably to other cancer screening programmes (breast, cervical), say Swedish researchers who have studied 20,000 men over 14 years. READ MORE>

This study (of PSA testing) shows that prostate cancer mortality was reduced almost by half over 14 years.

However, the risk of over-diagnosis is substantial and the number needed to treat is at least as high as in breast-cancer screening programmes.

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MEDICAL NEWS TODAY: Men with PSA levels in the “uncertainty zone” – that is, readings between 2 and 4 – may be more accurately diagnosed with a different kind of PSA test, using proenzyme (p2PSA). READ MORE>

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NEW PROSTATE CANCER INFOLINK: Austrian researchers claim they have developed a more accurate – and free – online calculator for men to work out their PSA doubling time. READ MORE>

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URO TODAY: Baseline PSA appears to be a reliable and independent predictor of death from prostate cancer. A baseline PSA of more than 4 ng/mL has been associated with higher risk of death from prostate cancer. READ MORE>

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NEW PROSTATE CANCER INFOLINK: How badly flawed was the US long-term randomised study of PSA testing, the one now being used by our Ministry of Health as one reason to reject PSA testing?

Very badly flawed, according to a new study. READ MORE>

It is well-understood that a problem with the data from the PLCO screening trial was that many men in the “control” (supposedly non-screened) arm of the trial did in fact get PSA testing and have digital rectal examinations during the time period of the trial (albeit outside the trial protocol and not at the trial centers).

But how bad was that “contamination” of the trial data? A new report by Pinsky et al. suggests that it was probably pretty bad.

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MEDICAL NEWS TODAY: Men who have a baseline PSA value of 10 or higher the first time they are tested are up to 11 times more likely to die from prostate cancer than are men with lower initial values. READ MORE>

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URO TODAY: New research findings suggest that PSA alone, in the under 40 age group, is not effective for detecting prostate cancer. READ MORE>

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NEW PROSTATE CANCER INFOLINK: Guidelines from several organizations now suggest that men should be thoroughly informed about the pros and cons of PSA testing before starting to receive such tests (regardless of frequency) as a means to assess possible risk for prostate cancer. READ MORE>

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NEW PROSTATE CANCER INFOLINK: A recent article in Cancer seems to further support Stamey’s contention (published in 2004) that — at least in the USA — the PSA test has a great deal less value as a screening test for prostate cancer today than it had when it was initially introduced in the 1980s and 1990s. READ MORE>

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