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Posts Tagged ‘Dutasteride’

URO TODAY: 5-Alpha reductase inhibitors, such as finasteride and dutasteride, may increase the accuracy of PSA tests in men with elevated or fluctuating PSA levels and previous negative biopsy, according to new data from researchers. READ MORE>

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URO TODAY: The dual inhibition of both types 1 and 2 of the testosterone-reducing enzyme 5-AR with the new drug dutasteride may prove more useful than another commonly used drug, finasteride, in treating prostate cancer. READ MORE>

A review just published by the Department of Urologic Sciences, University of British Columbia Vancouver says:

Normal growth and function of the prostate are contingent on the reduction of testosterone to dihydro-testosterone (DHT) by 5-alpha reductase (5-AR) enzymes types 1 and 2.

It has been theorised that an over-abundance of DHT may be implicated in the pathogenesis of both benign prostatic hyperplasia (BPH) and prostate cancer.Dutasteride inhibits both types 1 and 2, whereas finasteride inhibits type 2 only.

Available data show that dutasteride, in contrast to finasteride, provides greater suppression of DHT than finasteride, is able to shrink tumour volume quicker and more dramatically than finasteride, and is more effective against genetic variants of 5-AR than is finasteride.

Thus, full clinical investigations of these and other approaches to the inhibition of 5-AR are ongoing and results are greatly anticipated.

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May 1: BELLEVILLE NEWS-DEMOCRAT, ILLINOIS: Dutasteride has the potential to offer many thousands of men a way to reduce their risk of being diagnosed with prostate cancer. READ MORE>

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