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Posts Tagged ‘finasteride’

LA TIMES:  Most physicians are reluctant to prescribe the drug finasteride to prevent prostate cancer in older men with elevated risk of the disease, despite evidence that the drug can reduce risk by about a quarter. READ MORE>

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URO TODAY: 5-Alpha reductase inhibitors, such as finasteride and dutasteride, may increase the accuracy of PSA tests in men with elevated or fluctuating PSA levels and previous negative biopsy, according to new data from researchers. READ MORE>

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URO TODAY: Heavy, daily drinking increases the risk of high-grade prostate cancer, and heavy drinking makes finasteride ineffective for reducing prostate cancer risk, a study shows. READ MORE>

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URO TODAY: The dual inhibition of both types 1 and 2 of the testosterone-reducing enzyme 5-AR with the new drug dutasteride may prove more useful than another commonly used drug, finasteride, in treating prostate cancer. READ MORE>

A review just published by the Department of Urologic Sciences, University of British Columbia Vancouver says:

Normal growth and function of the prostate are contingent on the reduction of testosterone to dihydro-testosterone (DHT) by 5-alpha reductase (5-AR) enzymes types 1 and 2.

It has been theorised that an over-abundance of DHT may be implicated in the pathogenesis of both benign prostatic hyperplasia (BPH) and prostate cancer.Dutasteride inhibits both types 1 and 2, whereas finasteride inhibits type 2 only.

Available data show that dutasteride, in contrast to finasteride, provides greater suppression of DHT than finasteride, is able to shrink tumour volume quicker and more dramatically than finasteride, and is more effective against genetic variants of 5-AR than is finasteride.

Thus, full clinical investigations of these and other approaches to the inhibition of 5-AR are ongoing and results are greatly anticipated.

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JULY 14: URO TODAY: Researchers conclude heavy, daily drinking increases the risk of high-grade prostate cancer and that heavy drinking made finasteride ineffective for reducing prostate cancer risk. READ MORE>

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JULY 8:  HULIQ NEWS:  New research into prostate cancer drug finasteride – earlier thought to cause more aggressive cancer in some patients – suggests doctors can be less cautious about using it. READ MORE>

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REUTERS: The presence of multiple single nucleotide polymorphisms (DNA variations) associated with increased prostate cancer risk, coupled with a positive family history, accurately identify men at high risk for prostate cancer who might benefit from aggressive chemo-prevention with agents such as finasteride (drug treatment). READ MORE>

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