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Posts Tagged ‘Journal of the National Cancer Institute’

MEDICAL NEWS TODAY: The boom in cancer biomarker investments over the past 25 years has not translated into major clinical success. READ MORE>

The reasons for biomarker failures include problems with study design and interpretation, as well as statistical deficiencies, according to an article in The Journal of the National Cancer Institute.

if the biomarker is affected by a non-cancer disease, its utility for cancer detection may be compromised. For example, the prostate-specific antigen (PSA) biomarker, which is used to detect prostate cancer, is also elevated in benign prostatic hyperplasia.

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PROSTABLOG NZ: In what seems a perverse coincidence (for pro-testers), just as NZ’s Parliament begins an inquiry into prostate cancer screening and treatment,  an American report casting renewed doubt about PSA testing and rectal exams has re-ignited global debate.

The report says more than a million US men have had needless treatment for prostate cancer over two decades because the test/exam discover the presence of cancer but not its severity.

Discussion on the internet is widespread. See some of it HERE> and HERE> and HERE> and HERE> and HERE> and HERE> and HERE> and HERE> and HERE> and HERE> and HERE> and HERE>

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NEW PROSTATE CANCER INFOLINK: “Are we over-treating 50,000 men each year? Could it be even more?” asks Mike Scott, the sitemaster of America’s leading prostate cancer discussion website.

These questions begin his analysis of an article by Welch and Albertsen in this week’s issue of the Journal of the National Cancer Institute, which estimates how much “over-treatment” may have occurred during the 20-year period from 1986 and 2005. READ MORE>

It is their belief that it is of the order of 1 million men (an average of about 50,000 per year) or higher — and we have no reason to disagree with them.

Later, Mike writes:

If we can’t come up with a better way to differentiate between high risk and indolent prostate cancer (and quickly), then we need to come up with a better way to manage prostate cancer based on the information currently available.

The academic discussion is of intellectual interest, but is not a basis for clinical decision making.

We need a way to help men and their doctors make the right decision about management once a diagnosis is made (as opposed to telling them that diagnosing prostate cancer may be  the wrong thing to do).

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ABC NEWS HEALTH: Men with prostate cancer are being diagnosed at a younger age and earlier stage today than in years past, and the racial disparity in stage at diagnosis has decreased significantly, says a report in the Journal of the National Cancer Institute. READ MORE>

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I-HEALTH BULLETIN NEWS: Elevated insulin levels in the normal range appear to be associated with an increased risk of prostate cancer, according to a new study published in the Journal of the National Cancer Institute. READ MORE>

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MEDICAL NEWS TODAY: A public survey conducted in Europe found that the vast majority of people overestimate the life-saving benefits of breast and prostate cancer screening, according to a new study published in the Journal of the National Cancer Institute. READ MORE>

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JUNE 13: MODERN MEDICINE: The treatments for localised prostate cancer — prostatectomy, brachytherapy, and external radiation — have varied side effect profiles, and these should be taken into consideration in the selection of a treatment, according to a study published in the Journal of the National Cancer Institute. READ MORE>

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MAY 18: NATURAL NEWS: A new study in the Journal of the National Cancer Institute adds more evidence to the increasingly prevalent belief that regular prostate screenings may lead to more harm than good for older men. READ MORE>

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MEN’S HEALTH: Is prostate cancer being “over-diagnosed”? Right now, there doesn’t seem to be a clear answer, according to this analysis of the latest big study. But there are currently studies being conducted to try to determine when prostate cancer screenings should be offered, which tumours are the worrisome ones and those that are not. READ MORE>

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